Continuous noninvasive monitoring of cell growth in disposable bioreactors

Dynamic Simulation and Control of Microbial Cell Population in Continuous Bioreactors

Disposable bioreactors: from process development to production

Single-use bioreactors are commonly used for seeding stainless steel bioreactors or for producing material. The profitability of these equipments has been well demonstrated on more that decade. But few data on its scalability have been published. In 2010-2011, Merck Serono Biodevelopment performed a study in order to evaluate the performance of several disposable bioreactors. As different techn...

Optical imaging in microfluidic bioreactors enables oxygen monitoring for continuous cell culture.

For the first time, a fluorescence lifetime calibration method for an oxygen-sensitive dye ruthenium tris(2,2'-dipyridyl) dichloride hexahydrate (RTDP) is applied to image oxygen levels in poly(dimethyl siloxane) (PDMS) bioreactors containing living C2C12 mouse myoblasts. PDMS microsystems are broadly used in bioengineering applications due to their biocompatibility and ease of handling. For th...

Growth of Myxococcus xanthus in continuous-flow-cell bioreactors as a method for studying development.

Nutrient sensors and developmental timers are two classes of genes vital to the establishment of early development in the social soil bacterium Myxococcus xanthus. The products of these genes trigger and regulate the earliest events that drive the colony from a vegetative state to aggregates, which ultimately leads to the formation of fruiting bodies and the cellular differentiation of the indi...

Growth of Myxococcus xanthus in continuous flow cell bioreactors as a method for studying